Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 01 2020
09 01 2020
Historique:
received:
08
01
2019
accepted:
29
11
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Long-term epilepsy-associated tumors (LEATs) represent mostly benign brain tumors associated with drug-resistant epilepsy. The aim of the study was to investigate the specific transcriptional signatures of those tumors and characterize their underlying oncogenic drivers. A cluster analysis of 65 transcriptome profiles from three independent datasets resulted in four distinct transcriptional subgroups. The first subgroup revealed transcriptional activation of STAT3 and TGF-signaling pathways and contained predominantly dysembryoplastic neuroepithelial tumors (DNTs). The second subgroup was characterized by alterations in the MAPK-pathway and up-stream cascades including FGFR and EGFR-mediated signaling. This tumor cluster exclusively contained neoplasms with somatic BRAF
Identifiants
pubmed: 31919458
doi: 10.1038/s41598-019-56146-y
pii: 10.1038/s41598-019-56146-y
pmc: PMC6952384
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
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