Pseudoguaianelactones A-C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2.
Animals
Anti-Inflammatory Agents
/ chemistry
Crystallography, X-Ray
Cyclooxygenase 2
/ metabolism
Cytokines
/ metabolism
Lindera
/ chemistry
Lipopolysaccharides
/ pharmacology
Macrophages
/ cytology
Mice
Molecular Conformation
Nitric Oxide
/ metabolism
Nitric Oxide Synthase Type II
/ metabolism
Plant Roots
/ chemistry
RAW 264.7 Cells
Sesquiterpenes
/ chemistry
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
04 Feb 2020
04 Feb 2020
Historique:
pubmed:
11
1
2020
medline:
7
3
2020
entrez:
11
1
2020
Statut:
ppublish
Résumé
The pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5,7,7] ring system featuring an α-methylene-γ-lactone moiety, together with a new pseudoguaianelactone C (3) were isolated from the roots of Lindera glauca. Pseudoguaianelactones A-C (1-3) inhibited nitric oxide (NO) production, with IC
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
Lipopolysaccharides
0
Sesquiterpenes
0
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type II
EC 1.14.13.39
Cyclooxygenase 2
EC 1.14.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM