Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Animals
Carbon Tetrachloride
/ toxicity
Carcinoma, Hepatocellular
/ genetics
Chemical and Drug Induced Liver Injury, Chronic
/ genetics
Gene Regulatory Networks
Hepatitis B
/ genetics
Hepatitis, Chronic
/ genetics
Humans
Liver Cirrhosis
/ genetics
Liver Neoplasms
/ genetics
Male
Mice, Inbred C57BL
Non-alcoholic Fatty Liver Disease
/ genetics
Signal Transduction
/ drug effects
Gene networks
Liver injury
Regeneration
Transcriptomics
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
13
08
2019
accepted:
20
11
2019
pubmed:
11
1
2020
medline:
20
2
2021
entrez:
11
1
2020
Statut:
ppublish
Résumé
Inflammation has been recognized as essential for restorative regeneration. Here, we analyzed the sequential processes during onset of liver injury and subsequent regeneration based on time-resolved transcriptional regulatory networks (TRNs) to understand the relationship between inflammation, mature organ function, and regeneration. Genome-wide expression and TRN analysis were performed time dependently in mouse liver after acute injury by CCl
Identifiants
pubmed: 31919559
doi: 10.1007/s00204-019-02630-3
pii: 10.1007/s00204-019-02630-3
doi:
Substances chimiques
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-217Subventions
Organisme : FP7 Health
ID : 266838
Pays : International
Organisme : Nottingham City Primary Care Trust (GB)
ID : 267038
Pays : International
Organisme : Helmholtz Virtuelles Institut Multifunktionale Biomaterialien für die Medizin (DE)
ID : 0313854
Pays : International
Organisme : FONDECYT
ID : 1140549
Pays : International