Synchronous NET and colorectal cancer development: a case report.
Colorectal cancer
Everolimus
NET
Journal
Surgical case reports
ISSN: 2198-7793
Titre abrégé: Surg Case Rep
Pays: Germany
ID NLM: 101662125
Informations de publication
Date de publication:
09 Jan 2020
09 Jan 2020
Historique:
received:
18
07
2019
accepted:
31
12
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
1
2020
Statut:
epublish
Résumé
The incidence of synchronous gastrointestinal neuroendocrine tumors (GI-NETs) and colorectal cancer is very low. We present a 72-year-old man diagnosed with a rectal neuroendocrine tumor (NET) with multiple organ metastases and simultaneous sigmoid colon cancer. Although the NET was his prognostic factor, he underwent a laparoscopic sigmoidectomy at first because it was expected that the colon cancer would cause obstruction or bleeding during NET treatment. Subsequently, he started taking everolimus. We should consider surgical resection of the synchronous cancer before systemic therapy for a GI-NET regardless of the difference in prognosis between synchronous tumors, if the cancer may impair the continuation of systemic therapy.
Sections du résumé
BACKGROUND
BACKGROUND
The incidence of synchronous gastrointestinal neuroendocrine tumors (GI-NETs) and colorectal cancer is very low.
CASE PRESENTATION
METHODS
We present a 72-year-old man diagnosed with a rectal neuroendocrine tumor (NET) with multiple organ metastases and simultaneous sigmoid colon cancer. Although the NET was his prognostic factor, he underwent a laparoscopic sigmoidectomy at first because it was expected that the colon cancer would cause obstruction or bleeding during NET treatment. Subsequently, he started taking everolimus.
CONCLUSIONS
CONCLUSIONS
We should consider surgical resection of the synchronous cancer before systemic therapy for a GI-NET regardless of the difference in prognosis between synchronous tumors, if the cancer may impair the continuation of systemic therapy.
Identifiants
pubmed: 31919616
doi: 10.1186/s40792-020-0777-4
pii: 10.1186/s40792-020-0777-4
pmc: PMC6952479
doi:
Types de publication
Journal Article
Langues
eng
Pagination
10Références
Lancet. 2016 Mar 5;387(10022):968-977
pubmed: 26703889
J Natl Med Assoc. 1996 May;88(5):310-2
pubmed: 8667441
Dig Dis Sci. 1991 Jul;36(7):933-42
pubmed: 2070707
J Surg Case Rep. 2016 Mar 23;2016(3):null
pubmed: 27009325
Dis Colon Rectum. 2002 Jan;45(1):91-7
pubmed: 11786770
Am J Case Rep. 2017 Jun 06;18:626-630
pubmed: 28584225
Dis Colon Rectum. 2013 Aug;56(8):952-9
pubmed: 23838863
J Clin Oncol. 1987 Oct;5(10):1502-22
pubmed: 2443618
Endoscopy. 2009 Feb;41(2):162-5
pubmed: 19214898
Oncol Lett. 2012 Nov;4(5):910-914
pubmed: 23162621
Pathol Int. 2005 Aug;55(8):524-9
pubmed: 15998383
Curr Opin Gastroenterol. 2006 Sep;22(5):529-35
pubmed: 16891885
J Clin Oncol. 2008 Jun 20;26(18):3063-72
pubmed: 18565894
Ann N Y Acad Sci. 1994 Sep 15;733:46-55
pubmed: 7978895
Int J Colorectal Dis. 2008 Mar;23(3):325-7
pubmed: 18064472
Cancer. 1997 Feb 15;79(4):813-29
pubmed: 9024720
Oncology. 2000 Sep;59(3):229-37
pubmed: 11053991
BMC Cancer. 2010 Aug 23;10:448
pubmed: 20731845
Am J Gastroenterol. 1989 Feb;84(2):182-6
pubmed: 2644819
Gut. 2007 Jun;56(6):863-8
pubmed: 17213340
Case Rep Oncol Med. 2013;2013:930359
pubmed: 24368955
Ann N Y Acad Sci. 2004 Apr;1014:222-33
pubmed: 15153439
Gastrointest Cancer Res. 2008 May;2(3):113-25
pubmed: 19259290
J Am Coll Surg. 1995 Apr;180(4):427-32
pubmed: 7719546
J Exp Clin Cancer Res. 1998 Jun;17(2):139-48
pubmed: 9700573
J Surg Oncol. 2000 Dec;75(4):310-6
pubmed: 11135275
Ann Surg. 2004 Jul;240(1):117-22
pubmed: 15213627
Cancer. 2003 Feb 15;97(4):934-59
pubmed: 12569593
Virchows Arch. 2004 Jun;444(6):527-35
pubmed: 15057558
Ann Surg. 2010 Nov;252(5):750-5
pubmed: 21037430
Pancreas. 2010 Aug;39(6):767-74
pubmed: 20664474
Z Gastroenterol. 2012 Dec;50(12):1292-5
pubmed: 23225557
Anticancer Res. 2004 Mar-Apr;24(2C):1049-51
pubmed: 15154621