Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence.
MRSA
WCK 2349
WCK 771
alalevonadifloxacin
broad-spectrum antibiotic
levonadifloxacin
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
09
2019
accepted:
17
11
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
18
6
2020
Statut:
epublish
Résumé
Levonadifloxacin and its prodrug alalevonadifloxacin are novel broad-spectrum anti-MRSA agents belonging to the benzoquinolizine subclass of quinolone, formulated for intravenous and oral administration, respectively. Various in vitro and in vivo studies have established their antimicrobial spectrum against clinically significant Gram-positive, Gram-negative, atypical, and anaerobic pathogens. The potent activity of levonadifloxacin against MRSA, quinolone-resistant
Identifiants
pubmed: 31920285
doi: 10.2147/DDDT.S229882
pii: 229882
pmc: PMC6935279
doi:
Substances chimiques
Anti-Bacterial Agents
0
Quinolizines
0
Quinolones
0
levonadifloxacin
8WHH66L098
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4351-4365Informations de copyright
© 2019 Bhagwat et al.
Déclaration de conflit d'intérêts
All the authors are employees of Wockhardt Ltd, Mumbai, India. Dr Sachin S. Bhagwat reports holding Wockhardt shares. The authors report no other conflicts of interest in this work.
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