Opportunistic Respiratory Infections in HIV Patients Attending Sukraraj Tropical and Infectious Diseases Hospital in Kathmandu, Nepal.
CD4
HIV
bacterial and fungal infection
opportunistic infections
Journal
HIV/AIDS (Auckland, N.Z.)
ISSN: 1179-1373
Titre abrégé: HIV AIDS (Auckl)
Pays: New Zealand
ID NLM: 101515943
Informations de publication
Date de publication:
2019
2019
Historique:
received:
09
09
2019
accepted:
14
12
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
1
2020
Statut:
epublish
Résumé
Opportunistic bacterial and fungal infections are the major cause of morbidity and mortality among immune suppressed HIV-positive patients. The main objective of this study was to determine bacterial and fungal organisms causing respiratory infections and their susceptibility to commonly prescribed antimicrobials among HIV patients attending a tertiary infectious disease hospital in Kathmandu. Sputum samples were collected from the HIV-positive patients attending Sukraraj Tropical and Infectious Disease Hospital (STIDH) from August 2017 to March 2018. A total of 100 sputum samples were cultured on conventional bacterial and fungal culture media. Bacterial and fungal isolates were identified based on their colony characteristics, microscopic morphology and various biochemical tests. Antibiotic susceptibility test (AST) of bacterial isolates was performed by modified Kirby Bauer disc diffusion method. Out of 100 sputum samples cultured, 24% (n=24) showed bacterial growth, 42% (n=42) showed fungal growth and 10% (n=10) had both bacterial and fungal growth. Among bacteria, 91.6% (n=22) were monomicrobial and 8.4% (n=2) were polymicrobial in growth, of which, HIV-positive patients with a CD4 count less than 200 cells/µL are more vulnerable to opportunistic infections of bacterial and fungal origin. Early isolation, identification and appropriate treatment can reduce mortality due to co-infections. Routine screening of opportunistic pathogens is critical to contain the disease progression.
Identifiants
pubmed: 31920403
doi: 10.2147/HIV.S229531
pii: 229531
pmc: PMC6939395
doi:
Types de publication
Journal Article
Langues
eng
Pagination
357-367Informations de copyright
© 2019 KC et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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