Interactive Effects of Racial Identity and Repetitive Head Impacts on Cognitive Function, Structural MRI-Derived Volumetric Measures, and Cerebrospinal Fluid Tau and Aβ.
American football
biomarkers
chronic traumatic encephalopathy
cognitive function
concussion
magnetic resonance imaging
race
subconcussion
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
06
2019
accepted:
02
12
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
1
2020
Statut:
epublish
Résumé
Factors of increased prevalence among individuals with Black racial identity (e.g., cardiovascular disease, CVD) may influence the association between exposure to repetitive head impacts (RHI) from American football and later-life neurological outcomes. Here, we tested the interaction between racial identity and RHI on neurobehavioral outcomes, brain volumetric measures, and cerebrospinal fluid (CSF) total tau (t-tau), phosphorylated tau (p-tau 68 symptomatic male former NFL players (ages 40-69; Compared to White former NFL players, Black participants were 4 years younger ( Continued research on racial neurological disparities could provide insight into risk factors for long-term neurological disorders associated with American football play.
Sections du résumé
BACKGROUND
BACKGROUND
Factors of increased prevalence among individuals with Black racial identity (e.g., cardiovascular disease, CVD) may influence the association between exposure to repetitive head impacts (RHI) from American football and later-life neurological outcomes. Here, we tested the interaction between racial identity and RHI on neurobehavioral outcomes, brain volumetric measures, and cerebrospinal fluid (CSF) total tau (t-tau), phosphorylated tau (p-tau
METHODS
METHODS
68 symptomatic male former NFL players (ages 40-69;
RESULTS
RESULTS
Compared to White former NFL players, Black participants were 4 years younger (
CONCLUSION
CONCLUSIONS
Continued research on racial neurological disparities could provide insight into risk factors for long-term neurological disorders associated with American football play.
Identifiants
pubmed: 31920598
doi: 10.3389/fnhum.2019.00440
pmc: PMC6933867
doi:
Types de publication
Journal Article
Langues
eng
Pagination
440Subventions
Organisme : NINDS NIH HHS
ID : K23 NS102399
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS078337
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS093334
Pays : United States
Informations de copyright
Copyright © 2019 Alosco, Tripodis, Koerte, Jackson, Chua, Mariani, Haller, Foley, Martin, Palmisano, Singh, Green, Lepage, Muehlmann, Makris, Cantu, Lin, Coleman, Pasternak, Mez, Bouix, Shenton and Stern.
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