Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model.

aging astrocytes copper glial dystrophy iron microglia synchrotron radiation-based X-ray fluorescence elemental mapping zinc

Journal

Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824

Informations de publication

Date de publication:
2019
Historique:
received: 09 07 2019
accepted: 02 12 2019
entrez: 11 1 2020
pubmed: 11 1 2020
medline: 11 1 2020
Statut: epublish

Résumé

Microglia and astrocytes can quench metal toxicity to maintain tissue homeostasis, but with age, increasing glial dystrophy alongside metal dyshomeostasis may predispose the aged brain to acquire neurodegenerative diseases. The aim of the present study was to investigate age-related changes in brain metal deposition along with glial distribution in normal C57Bl/6J mice aged 2-, 6-, 19- and 27-months (

Identifiants

pubmed: 31920630
doi: 10.3389/fnagi.2019.00351
pmc: PMC6930884
doi:

Types de publication

Journal Article

Langues

eng

Pagination

351

Informations de copyright

Copyright © 2019 Ashraf, Michaelides, Walker, Ekonomou, Suessmilch, Sriskanthanathan, Abraha, Parkes, Parkes, Geraki and So.

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Auteurs

Azhaar Ashraf (A)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Christos Michaelides (C)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Thomas A Walker (TA)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Antigoni Ekonomou (A)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Maria Suessmilch (M)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Achvini Sriskanthanathan (A)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Semhar Abraha (S)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Adam Parkes (A)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Harold G Parkes (HG)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Kalotina Geraki (K)

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom.

Po-Wah So (PW)

Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Classifications MeSH