Interleukin-5 in the Pathophysiology of Severe Asthma.
IL-5
T2-high asthma
benralizumab
eosinophils
mepolizumab
reslizumab
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
10
2019
accepted:
02
12
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
1
2020
Statut:
epublish
Résumé
Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular mechanisms underlying the powerful actions of IL-5 finalized to the induction, maintenance, and amplification of eosinophilic inflammation. Therefore, IL-5 is a suitable target for add-on biological therapies based on either IL-5 inhibition (mepolizumab, reslizumab) or blockade of its receptor (benralizumab). These modern treatments can result in being definitely beneficial for patients with severe type 2 (T2)-high eosinophilic asthma, refractory to conventional anti-inflammatory drugs such as inhaled and even systemic corticosteroids.
Identifiants
pubmed: 31920718
doi: 10.3389/fphys.2019.01514
pmc: PMC6927944
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1514Informations de copyright
Copyright © 2019 Pelaia, Paoletti, Puggioni, Racca, Pelaia, Canonica and Heffler.
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