Human Apoptotic Cells, Generated by Extracorporeal Photopheresis, Modulate Allogeneic Immune Response.
NSG mice
apoptotic cell
immunomodulation
tolerance
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
07
2019
accepted:
26
11
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
11
2020
Statut:
epublish
Résumé
The induction of specific and sustainable tolerance is a challenging issue in organ transplantation. The discovery of the immunosuppressive properties of apoptotic cells in animal models has paved the way for their use in human transplantation. In this work, we aimed to define a stable, reproducible, and clinically compatible production procedure of human apoptotic cells (Apo-cells). Using a clinically approved extracorporeal photopheresis technique, we have produced and characterized phenotypically and functionally human apoptotic cells. These Apo-cells have immunosuppressive properties proved
Identifiants
pubmed: 31921167
doi: 10.3389/fimmu.2019.02908
pmc: PMC6930166
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2908Informations de copyright
Copyright © 2019 Pilon, Stehlé, Beldi-Ferchiou, Matignon, Thiolat, Burlion, Grondin, Birebent, Pirenne, Rouard, Lang, Marodon, Grimbert and Cohen.
Références
J Immunol. 2015 Mar 15;194(6):2569-77
pubmed: 25681340
Blood. 2006 Nov 15;108(10):3580-9
pubmed: 16882710
J Exp Med. 1998 Sep 7;188(5):887-96
pubmed: 9730890
J Exp Med. 2001 Aug 20;194(4):439-53
pubmed: 11514601
Br J Dermatol. 2006 Jan;154(1):7-20
pubmed: 16403088
J Immunol. 2000 Sep 15;165(6):3162-7
pubmed: 10975830
Blood. 2003 Jan 15;101(2):611-20
pubmed: 12393562
Am J Transplant. 2006 Jun;6(6):1297-311
pubmed: 16686754
Front Immunol. 2017 Jun 30;8:756
pubmed: 28713380
Immunity. 2004 Nov;21(5):643-53
pubmed: 15539151
N Engl J Med. 1998 Dec 10;339(24):1744-51
pubmed: 9845709
Blood. 2008 Oct 1;112(7):2667-74
pubmed: 18621929
Cell Transplant. 2015;24(12):2527-40
pubmed: 25198125
Mol Immunol. 2005 Jul;42(11):1345-54
pubmed: 15950730
J Immunol. 2008 Sep 1;181(5):3277-84
pubmed: 18713999
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):351-8
pubmed: 11773639
Cell Death Differ. 2006 Jan;13(1):41-52
pubmed: 15962005
J Clin Invest. 1998 Feb 15;101(4):890-8
pubmed: 9466984
Nat Clin Pract Oncol. 2006 Jun;3(6):302-14
pubmed: 16757968
N Engl J Med. 1987 Feb 5;316(6):297-303
pubmed: 3543674
Transplantation. 2010 Mar 15;89(5):492-9
pubmed: 20124954
J Clin Apher. 2019 Aug;34(4):450-460
pubmed: 30860623
Haematologica. 2012 Nov;97(11):1678-85
pubmed: 22581007
Diabetes. 2007 Aug;56(8):2116-23
pubmed: 17496235
Transfusion. 2015 Jul;55(7):1721-35
pubmed: 25807899
Nature. 1998 Mar 5;392(6671):86-9
pubmed: 9510252
J Exp Med. 2000 Feb 7;191(3):435-44
pubmed: 10662789
Biol Blood Marrow Transplant. 2014 Jan;20(1):58-65
pubmed: 24140121
Blood Adv. 2019 Apr 9;3(7):969-979
pubmed: 30936057
Blood. 2001 Jul 1;98(1):224-30
pubmed: 11418484
J Exp Med. 2000 Feb 7;191(3):423-34
pubmed: 10662788