Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing.
B cells
CCR7
CXCR4
homing
lymphopoiesis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
09
2019
accepted:
03
12
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
11
2020
Statut:
epublish
Résumé
The CXCL12-CXCR4 axis plays a key role in the retention of stem cells and progenitors in dedicated bone marrow niches. It is well-known that CXCR4 responsiveness in B lymphocytes decreases dramatically during the final stages of their development in the bone marrow. However, the molecular mechanism underlying this regulation and whether it plays a role in B-cell homeostasis remain unknown. In the present study, we show that the differentiation of pre-B cells into immature and mature B cells is accompanied by modifications to the relative expression of chemokine receptors, with a two-fold downregulation of CXCR4 and upregulation of CCR7. We demonstrate that expression of CCR7 in B cells is involved in the selective inactivation of CXCR4, and that mature B cells from CCR7
Identifiants
pubmed: 31921208
doi: 10.3389/fimmu.2019.02970
pmc: PMC6930800
doi:
Substances chimiques
CXCR4 protein, mouse
0
Ccr7 protein, mouse
0
Chemokine CXCL12
0
Cxcl12 protein, mouse
0
Receptors, CCR7
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2970Informations de copyright
Copyright © 2019 Mcheik, Van Eeckhout, De Poorter, Galés, Parmentier and Springael.
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