Dysregulation of adenosine kinase isoforms in breast cancer.
adenosine kinase
adenosine kinase isoforms
breast cancer
metastasis
proliferation
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
31 Dec 2019
31 Dec 2019
Historique:
received:
05
08
2019
accepted:
07
11
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
1
2020
Statut:
epublish
Résumé
Dysregulated adenosine signaling pathway has been evidenced in the pathogenesis of breast cancer. However, the role of adenosine kinase (ADK) in tumorigenesis remains unclear while it crucially regulates the removal and availability of adenosine. ADK has two isoforms that localize to discrete subcellular spaces: i.e., nuclear, long-isoform (ADK-L) and cytosolic, short-isoform (ADK-S). We hypothesized that these two ADK isoforms would be differentially expressed in breast cancer and may contribute to divergent cellular actions in cancer. In this study, we examined the expression profiles of ADK isoforms in breast cancer tissues from 46 patient and followed up with an
Identifiants
pubmed: 31921385
doi: 10.18632/oncotarget.27364
pii: 27364
pmc: PMC6944449
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7238-7250Informations de copyright
Copyright: © 2019 Shamloo et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors have no conflicts of interests.
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