A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.
Aging
Biomarkers of diet quality
Cognitive decline
DHA
EPA
Elderly
Homocysteine
Metabolomics
Nutrient biomarkers
Omega-3 fatty acids
Vitamin D
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
1
2020
Statut:
epublish
Résumé
Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years. The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0-3). The primary outcome in MAPT was a cognitive composite Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement ( Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.
Identifiants
pubmed: 31921969
doi: 10.1016/j.trci.2019.11.004
pii: S2352-8737(19)30090-3
pmc: PMC6944714
doi:
Types de publication
Journal Article
Langues
eng
Pagination
953-963Subventions
Organisme : NIA NIH HHS
ID : P30 AG008017
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG053760
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066518
Pays : United States
Investigateurs
Bruno Vellas
(B)
Sophie Guyonnet
(S)
Isabelle Carrié
(I)
Lauréane Brigitte
(L)
Catherine Faisant
(C)
Françoise Lala
(F)
Julien Delrieu
(J)
Hélène Villars
(H)
Emeline Combrouze
(E)
Carole Badufle
(C)
Audrey Zueras
(A)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Christophe Morin
(C)
Gabor Abellan Van Kan
(GA)
Charlotte Dupuy
(C)
Yves Rolland
(Y)
Céline Caillaud
(C)
Pierre-Jean Ousset
(PJ)
Françoise Lala
(F)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 The Authors.
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