Alcohol Oxidoreductases / antagonists & inhibitors Animals Antitubercular Agents / chemistry Bacterial Proteins / antagonists & inhibitors Enzyme Inhibitors / chemistry Humans Male Mice Morpholines / chemistry Mycobacterium tuberculosis / drug effects Pyrimidines / chemistry Tuberculosis / drug therapy

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
12 03 2020
Historique:
pubmed: 11 1 2020
medline: 1 9 2020
entrez: 11 1 2020
Statut: ppublish

Résumé

Decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1) is an essential enzyme in

Identifiants

DOI: 10.1021/acs.jmedchem.9b01561 PMID: 31922409
pubmed: 31922409
doi: 10.1021/acs.jmedchem.9b01561
doi:

Substances chimiques

Antitubercular Agents 0
Bacterial Proteins 0
Enzyme Inhibitors 0
Morpholines 0
Pyrimidines 0
Alcohol Oxidoreductases EC 1.1.-
DprE1 protein, Mycobacterium tuberculosis EC 1.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2557-2576

Auteurs

Jennifer A Borthwick (JA)

Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
ORCID: 0000-0002-6740-4232

Carlos Alemparte (C)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
ORCID: 0000-0001-5521-8304

Ian Wall (I)

Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Benjamin C Whitehurst (BC)

Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Argyrides Argyrou (A)

Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
ORCID: 0000-0003-3141-9122

Glenn Burley (G)

Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.
ORCID: 0000-0002-4896-113X

Paco de Dios-Anton (P)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.

Laura Guijarro (L)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.

Maria Candida Monteiro (MC)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.

Fatima Ortega (F)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.

Colin J Suckling (CJ)

Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.

Julia Castro Pichel (JC)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.

Monica Cacho (M)

Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
ORCID: 0000-0001-6270-5370

Robert J Young (RJ)

Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
ORCID: 0000-0002-7763-0575

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases ›
questionsmedicales.fr › Eucaryotes › Animaux ›
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes ›
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris ›
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Morpholines ›
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis ›
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines ›
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose ›