PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats.
Animals
Animals, Newborn
Chronic Disease
Cyclic N-Oxides
/ pharmacology
Enzyme Inhibitors
Female
Free Radical Scavengers
Hypoxia
/ metabolism
Indoles
/ pharmacology
Maleimides
/ pharmacology
Organophosphorus Compounds
/ pharmacology
Oxidative Stress
Pregnancy
Protein Kinase C beta
/ antagonists & inhibitors
Pulmonary Artery
/ drug effects
Pulmonary Circulation
Rats
Reactive Oxygen Species
Spin Labels
Ubiquinone
/ analogs & derivatives
Vasoconstriction
Vasoconstrictor Agents
/ pharmacology
PKCβ
mitochondria
oxidative stress
pulmonary hypertension
vascular disease
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
11
1
2020
medline:
6
5
2020
entrez:
11
1
2020
Statut:
ppublish
Résumé
Reactive oxygen species (ROS), mitochondrial dysfunction, and excessive vasoconstriction are important contributors to chronic hypoxia (CH)-induced neonatal pulmonary hypertension. On the basis of evidence that PKCβ and mitochondrial oxidative stress are involved in several cardiovascular and metabolic disorders, we hypothesized that PKCβ and mitochondrial ROS (mitoROS) signaling contribute to enhanced pulmonary vasoconstriction in neonatal rats exposed to CH. To test this hypothesis, we examined effects of the PKCβ inhibitor LY-333,531, the ROS scavenger 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine (TEMPOL), and the mitochondrial antioxidants mitoquinone mesylate (MitoQ) and (2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride (MitoTEMPO) on vasoconstrictor responses in saline
Identifiants
pubmed: 31922892
doi: 10.1152/ajpheart.00629.2019
pmc: PMC7052628
doi:
Substances chimiques
Cyclic N-Oxides
0
Enzyme Inhibitors
0
Free Radical Scavengers
0
Indoles
0
Maleimides
0
Organophosphorus Compounds
0
Reactive Oxygen Species
0
Spin Labels
0
Vasoconstrictor Agents
0
Ubiquinone
1339-63-5
mitoquinone
47BYS17IY0
ruboxistaurin
721809WQCP
PRKCB protein, human
EC 2.7.11.13
Protein Kinase C beta
EC 2.7.11.13
tempol
U78ZX2F65X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H470-H483Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL131334
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132883
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111084
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088192
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007736
Pays : United States
Organisme : NIGMS NIH HHS
ID : K12 GM088021
Pays : United States
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