HYPERAUTOFLUORESCENT SPOTS IN ACUTE OCULAR TOXOPLASMOSIS: A New Indicator of Outer Retinal Inflammation.
Acute Disease
Adolescent
Adult
Biomarkers
Coloring Agents
/ administration & dosage
Female
Fluorescein Angiography
Humans
Indocyanine Green
/ administration & dosage
Inflammation
/ diagnosis
Male
Middle Aged
Multimodal Imaging
Optical Imaging
Retinitis
/ diagnosis
Retrospective Studies
Tomography, Optical Coherence
Toxoplasmosis, Ocular
/ diagnosis
Young Adult
Journal
Retina (Philadelphia, Pa.)
ISSN: 1539-2864
Titre abrégé: Retina
Pays: United States
ID NLM: 8309919
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
11
1
2020
medline:
4
9
2021
entrez:
11
1
2020
Statut:
ppublish
Résumé
The aim of this study was to describe the fundus autofluorescence patterns in acute ocular toxoplasmosis (OT) and to correlate these findings with other imaging. A retrospective multicenter case series of 27 eyes from 27 patients with acute onset of posterior OT was conducted. Multimodal imaging including fundus autofluorescence was performed at diagnosis and during follow-up. All OT lesions were hypoautofluorescent on fundus autofluorescence imaging. Fourteen patients (51.8%) also had hyperautofluorescent spots around the active foci that disappeared after retinal photobleaching. Although these spots were not seen on early phase of indocyanine green angiography, they become hypofluorescent in the late phase without choriocapillaris flow impairment on optical coherence tomography angiography. On B-scan spectral domain optical coherence tomography, spots corresponded to outer retinal alterations in all cases. All hyperautofluorescent spots disappeared during follow-up as acute OT resolved. Younger patients and those with more posterior inflammatory symptoms (vasculitis and/or papillitis) were more frequent with the presence of hyperautofluorescent spots. Ocular toxoplasmosis may trigger a transient outer retinal disruption in eyes with marked inflammatory symptoms of the younger patients.
Identifiants
pubmed: 31923122
doi: 10.1097/IAE.0000000000002759
pii: 00006982-202012000-00018
doi:
Substances chimiques
Biomarkers
0
Coloring Agents
0
Indocyanine Green
IX6J1063HV
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2396-2402Références
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