The impact of waiting intervals on survival outcomes of patients with endometrial cancer: A systematic review of the literature.
Carcinoma
/ mortality
Chemoradiotherapy, Adjuvant
/ statistics & numerical data
Disease-Free Survival
Endometrial Neoplasms
/ mortality
Female
Gynecologic Surgical Procedures
/ statistics & numerical data
Humans
Neoplasm Staging
Proportional Hazards Models
Radiotherapy, Adjuvant
/ statistics & numerical data
Time-to-Treatment
/ statistics & numerical data
Endometrial cancer
Systematic review
Time to radiation
Time to surgery
Wait intervals
Wait time
Journal
European journal of obstetrics, gynecology, and reproductive biology
ISSN: 1872-7654
Titre abrégé: Eur J Obstet Gynecol Reprod Biol
Pays: Ireland
ID NLM: 0375672
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
26
10
2019
revised:
30
12
2019
accepted:
02
01
2020
pubmed:
11
1
2020
medline:
15
12
2020
entrez:
11
1
2020
Statut:
ppublish
Résumé
The purpose of the present systematic review is to summarize the available evidence concerning the impact of investigated intervals of treatment (diagnosis to surgery and surgical treatment to adjuvant therapy) on survival outcomes of endometrial cancer patients. We searched Medline, Scopus, Clinicaltrials.gov, EMBASE, and Google Scholar databases from inception until July 31st 2019. All observational studies were considered eligible for inclusion. Investigated outcomes were retrieved and analyzed as well as factors that influenced the extent of wait intervals. Overall, 12 articles were included that investigated the influence of wait intervals on survival outcomes of 773,185 patients. We observed that the proposed cut-off values for interval periods, the reported survival outcomes as well as the tumor characteristics of included patients varied significantly among the studies that were included. Given these differences, meta-analysis of survival outcomes was not possible. The most common cut-off for the time to surgery interval was 6 weeks and for the time to adjuvant treatment 9 weeks. The percentage of patients that was treated within this limit ranged between 24 and 74 %. Given this information we believe that the optimal interval between diagnosis and surgical treatment of endometrial cancer patients should not exceed eight weeks (keeping in mind that surgery within the first two weeks may be a negative prognostic factor), whereas between surgery and adjuvant therapy should be limited to a maximum of nine weeks. Future studies should evaluate factors that seem to influence the extent of waiting intervals to help determine the limitations of healthcare systems.
Identifiants
pubmed: 31923876
pii: S0301-2115(20)30004-X
doi: 10.1016/j.ejogrb.2020.01.004
pii:
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report that they have no conflicts of interest to disclose.