Smart drug delivery system activated by specific biomolecules.
Drug delivery
Poly(N-isopropylacrylamide)
Smart polymer
Stimuli-sensitive polymer
Triggering agent
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
06
05
2019
revised:
30
09
2019
accepted:
17
11
2019
entrez:
12
1
2020
pubmed:
12
1
2020
medline:
3
6
2020
Statut:
ppublish
Résumé
Essentially, the human body can release in different disease conditions specific biomolecules such as histamines when the body encounters a toxic substance, antibodies which are part of the body's natural immune response or nitric oxide as a cardiovascular signalling molecule. Design and development of "intelligent" delivery systems able to release the therapeutic agent only in the presence of bioactive compounds was presented here. Poly(N-isopropylacrylamide-co-N-(3-aminopropyl)methacrylamide)) (poly(NIPAAm-co-APM)) was synthesized as an exciting pH/temperature sensitive copolymer. Under physiological conditions (pH = 7.4), the APM in copolymer is in the ionized state (pK
Identifiants
pubmed: 31923948
pii: S0928-4931(19)31647-9
doi: 10.1016/j.msec.2019.110466
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Drug Carriers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110466Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.