Targeted Optical Imaging of the Glucagonlike Peptide 1 Receptor Using Exendin-4-IRDye 800CW.


Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
07 2020
Historique:
received: 29 07 2019
accepted: 13 11 2019
pubmed: 12 1 2020
medline: 29 12 2020
entrez: 12 1 2020
Statut: ppublish

Résumé

The treatment of choice for insulinomas and focal lesions in congenital hyperinsulinism (CHI) is surgery. However, intraoperative detection can be challenging. This challenge could be overcome with intraoperative fluorescence imaging, which provides real-time lesion detection with a high spatial resolution. Here, a novel method for targeted near-infrared (NIR) fluorescence imaging of glucagonlike peptide 1 receptor (GLP-1R)-positive lesions, using the GLP-1 agonist exendin-4 labeled with IRDye 800CW, was examined in vitro and in vivo.

Identifiants

pubmed: 31924726
pii: jnumed.119.234542
doi: 10.2967/jnumed.119.234542
pmc: PMC7383075
doi:

Substances chimiques

Benzenesulfonates 0
Glucagon-Like Peptide-1 Receptor 0
IRDye 800CW 0
Indoles 0
Exenatide 9P1872D4OL

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1066-1071

Informations de copyright

© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

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Auteurs

Marti Boss (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands marti.boss@radboudumc.nl.

Desiree Bos (D)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Cathelijne Frielink (C)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Gerwin Sandker (G)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Selen Ekim (S)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Camille Marciniak (C)

Department of General and Endocrine Surgery, University Hospital 2 Lille, Lille, France.

Francois Pattou (F)

Department of General and Endocrine Surgery, University Hospital 2 Lille, Lille, France.

Go van Dam (G)

Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands; and.

Sanne van Lith (S)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Maarten Brom (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Martin Gotthardt (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Mijke Buitinga (M)

Department of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.

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Classifications MeSH