Prognostic value of
99mTc-ECD brain perfusion SPECT
Atrial fibrillation
Dementia
Prognosis
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
10 Jan 2020
10 Jan 2020
Historique:
received:
06
10
2019
accepted:
30
12
2019
entrez:
12
1
2020
pubmed:
12
1
2020
medline:
12
1
2020
Statut:
epublish
Résumé
Patients with atrial fibrillation (AF) and dementia experience reduced quality of life and increased mortality. Technetium 99m ECD brain perfusion single-photon emission computed tomography ( Of a total of 405 consecutive patients diagnosed with AF as cardiac outpatients with dementia using the Mini-Mental State Examination by neurologists or psychiatrists, we identified 170 patients (81 ± 10 years) who underwent During a mean follow-up of 1258 ± 1044 days, 62 MACE occurred. There was no significant difference in MACE between AD and VD (33%, vs. 44%, p = 0.153). The multivariable Cox model confirmed that the higher Z-score of temporo-parieto-occipital lobe was associated with increased MACE compared to the lower group (HR 2.521, 95% CI 1.465-4.337, p < 0.001). This study demonstrated that decreased cerebral blood flow in the temporo-parieto-occipital lobe could be a potential prognostic value in patients with both AF and dementia.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with atrial fibrillation (AF) and dementia experience reduced quality of life and increased mortality. Technetium 99m ECD brain perfusion single-photon emission computed tomography (
METHODS
METHODS
Of a total of 405 consecutive patients diagnosed with AF as cardiac outpatients with dementia using the Mini-Mental State Examination by neurologists or psychiatrists, we identified 170 patients (81 ± 10 years) who underwent
RESULTS
RESULTS
During a mean follow-up of 1258 ± 1044 days, 62 MACE occurred. There was no significant difference in MACE between AD and VD (33%, vs. 44%, p = 0.153). The multivariable Cox model confirmed that the higher Z-score of temporo-parieto-occipital lobe was associated with increased MACE compared to the lower group (HR 2.521, 95% CI 1.465-4.337, p < 0.001).
CONCLUSION
CONCLUSIONS
This study demonstrated that decreased cerebral blood flow in the temporo-parieto-occipital lobe could be a potential prognostic value in patients with both AF and dementia.
Identifiants
pubmed: 31925616
doi: 10.1186/s13550-019-0589-3
pii: 10.1186/s13550-019-0589-3
pmc: PMC6954156
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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