Role of noncanonical Wnt ligands and Ror-family receptor tyrosine kinases in the development, regeneration, and diseases of the musculoskeletal system.
Ror-family receptor tyrosine kinases
bone resorption
locomotive organs
musculoskeletal system
osteopenia
sarcopenia
skeletal muscle regeneration
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Titre abrégé: Dev Dyn
Pays: United States
ID NLM: 9201927
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
29
11
2019
revised:
26
12
2019
accepted:
06
01
2020
pubmed:
12
1
2020
medline:
19
1
2022
entrez:
12
1
2020
Statut:
ppublish
Résumé
The Ror-family receptor tyrosine kinases (RTKs), consisting of Ror1 and Ror2, play crucial roles in morphogenesis and formation of various tissues/organs, including the bones and skeletal muscles, the so-called musculoskeletal system, during embryonic development, by acting as receptors or coreceptors for a noncanonical Wnt protein Wnt5a. Furthermore, several lines of evidence have indicated that Ror1 and/or Ror2 play critical roles in the regeneration and maintenance of the musculoskeletal system in adults. Considering the anatomical and functional relationship between the skeleton and skeletal muscles, their structural and functional association might be tightly regulated during their embryonic development, development after birth, and their regeneration after injury in adults. Importantly, in addition to their congenital anomalies, much attention has been paid onto the age-related disorders of the musculoskeletal system, including osteopenia and sarcopenia, which affect severely the quality of life. In this article, we overview recent advances in our understanding of the roles of Ror1- and/or Ror2-mediated signaling in the embryonic development, regeneration in adults, and congenital and age-related disorders of the musculoskeletal system and discuss possible therapeutic approaches to locomotive syndromes by modulating Ror1- and/or Ror2-mediated signaling.
Substances chimiques
Ligands
0
Wnt Proteins
0
Receptor Tyrosine Kinase-like Orphan Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-38Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP19gm1210005
Organisme : Japan Agency for Medical Research and Development
ID : JP19gm5010001
Organisme : Japan Society for the Promotion of Science
ID : 16H02691
Organisme : Japan Society for the Promotion of Science
ID : 18H053
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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