Modification of the effects of prenatal manganese exposure on child neurodevelopment by maternal anemia and iron deficiency.
Age Factors
Anemia, Iron-Deficiency
/ blood
Biomarkers
/ blood
Child
Child Development
Child, Preschool
Female
Ferritins
/ blood
Gestational Age
Hemoglobins
/ metabolism
Humans
Male
Manganese
/ adverse effects
Mexico
Nervous System
/ growth & development
Neurodevelopmental Disorders
/ diagnosis
Pregnancy
Pregnancy Complications, Hematologic
/ blood
Prenatal Exposure Delayed Effects
Prospective Studies
Risk Assessment
Risk Factors
Sex Factors
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
16
08
2019
accepted:
29
12
2019
revised:
22
11
2019
pubmed:
12
1
2020
medline:
22
7
2021
entrez:
12
1
2020
Statut:
ppublish
Résumé
We evaluated: (1) associations of prenatal manganese (Mn) levels with child neurodevelopment at 4-6 years; (2) effect modification by maternal anemia and iron deficiency; and (3) sex-specific effects. We measured blood Mn, hemoglobin, and serum ferritin in mothers at the second trimester, third trimester, and at birth, and in cord blood from a prospective birth cohort in Mexico City (n = 571). McCarthy Scales of Children's Abilities were measured at 4-6 years. Using linear regression, we estimated associations between prenatal Mn and neurodevelopment, examined anemia and iron deficiency as effect modifiers, and analyzed associations by child sex. No direct associations were observed between Mn, anemia, or iron deficiency and McCarthy Scales. Second trimester iron deficiency and third trimester anemia modified the effect of Mn on child neurodevelopment. For instance, second trimester Mn was positively associated child memory scores in mother's with normal ferritin (1.85 (0.02, 3.45)), but negatively associated in mother's with low ferritin (-2.41 (-5.28, 0.47), interaction P value = 0.01), a pattern observed across scales. No effect modification at birth or in cord blood was observed. Anemia/iron deficiency during pregnancy may modify Mn impacts on child neurodevelopment, particularly in boys.
Sections du résumé
BACKGROUND
We evaluated: (1) associations of prenatal manganese (Mn) levels with child neurodevelopment at 4-6 years; (2) effect modification by maternal anemia and iron deficiency; and (3) sex-specific effects.
METHODS
We measured blood Mn, hemoglobin, and serum ferritin in mothers at the second trimester, third trimester, and at birth, and in cord blood from a prospective birth cohort in Mexico City (n = 571). McCarthy Scales of Children's Abilities were measured at 4-6 years. Using linear regression, we estimated associations between prenatal Mn and neurodevelopment, examined anemia and iron deficiency as effect modifiers, and analyzed associations by child sex.
RESULTS
No direct associations were observed between Mn, anemia, or iron deficiency and McCarthy Scales. Second trimester iron deficiency and third trimester anemia modified the effect of Mn on child neurodevelopment. For instance, second trimester Mn was positively associated child memory scores in mother's with normal ferritin (1.85 (0.02, 3.45)), but negatively associated in mother's with low ferritin (-2.41 (-5.28, 0.47), interaction P value = 0.01), a pattern observed across scales. No effect modification at birth or in cord blood was observed.
CONCLUSIONS
Anemia/iron deficiency during pregnancy may modify Mn impacts on child neurodevelopment, particularly in boys.
Identifiants
pubmed: 31926485
doi: 10.1038/s41390-020-0754-4
pii: 10.1038/s41390-020-0754-4
pmc: PMC7351595
mid: NIHMS1548319
doi:
Substances chimiques
Biomarkers
0
Hemoglobins
0
Manganese
42Z2K6ZL8P
Ferritins
9007-73-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-333Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES026033
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021357
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES013744
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028522
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES014930
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
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