Expression of nucleostemin in odontogenic cysts and tumors.

Ameloblastoma / metabolism Cell Nucleus / metabolism GTP-Binding Proteins / metabolism Humans Nuclear Proteins / metabolism Odontogenic Cysts / metabolism
Dentigerous cyst Nucleostemin Odontogenic keratocyst Unicystic ameloblastoma

Journal

Experimental and molecular pathology
ISSN: 1096-0945
Titre abrégé: Exp Mol Pathol
Pays: Netherlands
ID NLM: 0370711

Informations de publication

Date de publication:
04 2020
Historique:
received: 02 11 2019
revised: 28 12 2019
accepted: 08 01 2020
pubmed: 14 1 2020
medline: 21 7 2020
entrez: 14 1 2020
Statut: ppublish

Résumé

Considering the unique clinical behavior of odontogenic cysts and tumors, this study aimed to assess the expression of nucleostemin in odontogenic cysts and tumors by immunohistochemical (IHC) staining. This retrospective study evaluated 50 samples including 13 samples of unicystic ameloblastoma (UA), 10 samples of solid ameloblastoma (SA), 10 samples of odontogenic keratocyst (OKC) and 17 samples of dentigerous cyst (DC) by IHC staining. The stained slides were evaluated under a light microscope. Number of positively stained cells for nucleostemin marker was counted in five random areas per 100 cells under x400 magnification. The labeling index (LI) for nucleostemin was calculated by dividing the number of positively stained cells by the total number of counted cells in each lesion multiplied by 100. Positive staining for nucleostemin marker was observed in 100% of SA,100% of UA, 100% of OKC and 5 samples of DC (29.4%). The LI for nucleostemin marker in SA (median: 70.5), UA (median: 50) and OKC (median: 52) samples was significantly higher than that in DC (median: 0.00) (P = .001). This study showed an increased expression of nucleostemin in ameloblastoma and OKC, which suggests that stemness may be related to development of these lesions, their invasive behavior and high rate of recurrence.

Identifiants

DOI: 10.1016/j.yexmp.2020.104376 PMID: 31926976
pubmed: 31926976
pii: S0014-4800(19)30838-X
doi: 10.1016/j.yexmp.2020.104376
pii:
doi:

Substances chimiques

GNL3 protein, human 0
Nuclear Proteins 0
GTP-Binding Proteins EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104376

Informations de copyright

Copyright © 2020. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None of the authors has any conflict of interest to disclose.

Auteurs

Azadeh Andisheh-Tadbir (A)

Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Mohammad Ali Ranjbar (MA)

Department of Oral and Maxillofacial Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Amir Abbas Shiri (AA)

Undergraduate Student, Shiraz University of Medical Sciences, Shiraz, Iran.

Maryam Mardani (M)

Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mardanim@sums.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs odontogènes › Améloblastome › Expression of nucleostemin in odontogenic...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Expression of nucleostemin in odontogenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Expression of nucleostemin in odontogenic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expression of nucleostemin in odontogenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Expression of nucleostemin in odontogenic...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la mâchoire › Kystes de la mâchoire › Kystes odontogènes › Expression of nucleostemin in odontogenic...