Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index.
Age related macular degeneration
Artificial intelligence
Choroid
Choroidal vascularity index
Optical coherence tomography
Uveitis
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
25
10
2019
revised:
30
12
2019
accepted:
04
01
2020
pubmed:
14
1
2020
medline:
15
12
2020
entrez:
14
1
2020
Statut:
ppublish
Résumé
The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced inconsistent findings, partly due to the physical inaccessibility of the choroid and the lack of reliable biomarkers. With the advancements in optical coherence tomography technology, our group has developed a novel quantitative imaging biomarker known as the choroidal vascularity index (CVI), defined as the ratio of vascular area to the total choroidal area. CVI is a potential tool in establishing early diagnoses, monitoring disease progression and prognosticating patients. CVI has been reported in existing literature as a robust marker in numerous retinal and choroidal diseases. In this review, we will discuss the current role of CVI with reference to existing literature, and make postulations about its potential and future applications.
Identifiants
pubmed: 31927136
pii: S1350-9462(20)30001-X
doi: 10.1016/j.preteyeres.2020.100829
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100829Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.