New withanolides with anti-inflammatory activity from the leaves of Datura metel L.
Anti-inflammatory activity
Datura metel L.
NF-κB
Withanolides
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
12
09
2019
revised:
02
12
2019
accepted:
21
12
2019
pubmed:
14
1
2020
medline:
9
3
2021
entrez:
14
1
2020
Statut:
ppublish
Résumé
Twenty three undescribed withanolides, daturmetelides A-W (1-23), were isolated from 70% EtOH extract of the leaves of Datura metel L. The structural characterizations and relative configurations of 1-23 were elucidated by extensive spectroscopic analysis as well as by comparison with literature values. The absolute configurations of 1 and 3 were determined by X-ray crystallography. Bioassay results showed that 1 and 7 exhibited moderate inhibitory effects against NO production in lipopolysaccharide-stimulated RAW 264.7 cells (IC
Identifiants
pubmed: 31927334
pii: S0045-2068(19)31508-1
doi: 10.1016/j.bioorg.2019.103541
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Withanolides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103541Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.