Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country.
Journal
International journal of nephrology
ISSN: 2090-214X
Titre abrégé: Int J Nephrol
Pays: United States
ID NLM: 101546753
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
03
2019
revised:
01
07
2019
accepted:
05
09
2019
entrez:
14
1
2020
pubmed:
14
1
2020
medline:
14
1
2020
Statut:
epublish
Résumé
In Colombia, the genetic background of the populations was shaped by different levels of admixture between Natives, European, and Africans. Approximately 35.363 patients have diagnosed chronic kidney disease and according to population studies, 10.4% of these patients are Afro-descendant. We aim to assess the frequency of APOL1 variants G1 and G2 in Afro-descendant patients with ESRD treated at la Fundacion Valle del Lili University Hospital in Cali, Colombia. This is an observational cross-sectional study. Afro-descendant patients with ESRD in waitlist or recipients of kidney transplant were evaluated. Clinical data were collected from the electronic medical records. Genotyping was carried out by amplification of the exon 7 of the APOL1 gene. For the identification of risk genotypes, the bioinformatics tool BLAST was used. We enrolled 102 participants. The frequency of APOL1 risk variants was 67.2%, in which 24.5% (
Identifiants
pubmed: 31929905
doi: 10.1155/2019/7076326
pmc: PMC6935820
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7076326Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 Carlos E. Duran et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
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