Molecular Interactions Between Components of the Circadian Clock and the Immune System.
circadian
immune system
inflammation
rhythm
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
29 05 2020
29 05 2020
Historique:
received:
01
10
2019
revised:
18
12
2019
accepted:
19
12
2019
pubmed:
14
1
2020
medline:
29
12
2020
entrez:
14
1
2020
Statut:
ppublish
Résumé
The immune system is under control of the circadian clock. Many of the circadian rhythms observed in the immune system originate in direct interactions between components of the circadian clock and components of the immune system. The main means of circadian control over the immune system is by direct control of circadian clock proteins acting as transcription factors driving the expression or repression of immune genes. A second circadian control of immunity lies in the acetylation or methylation of histones to regulate gene transcription or inflammatory proteins. Furthermore, circadian clock proteins can engage in direct physical interactions with components of key inflammatory pathways such as members of the NFκB protein family. This regulation is transcription independent and allows the immune system to also reciprocally exert control over circadian clock function. Thus, the molecular interactions between the circadian clock and the immune system are manifold. We highlight and discuss here the recent findings with respect to the molecular mechanisms that control time-of-day-dependent immunity. This review provides a structured overview focusing on the key circadian clock proteins and discusses their reciprocal interactions with the immune system.
Identifiants
pubmed: 31931006
pii: S0022-2836(20)30028-0
doi: 10.1016/j.jmb.2019.12.044
pmc: PMC7322557
pii:
doi:
Substances chimiques
Histones
0
Transcription Factors
0
CLOCK Proteins
EC 2.3.1.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3700-3713Subventions
Organisme : European Research Council
ID : 635872
Pays : International
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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