Development of thermosensitive hydrogel containing methylene blue for topical antimicrobial photodynamic therapy.

Anti-Infective Agents / chemistry Drug Carriers / chemistry Drug Liberation Hydrogels / chemistry Light Methicillin-Resistant Staphylococcus aureus / drug effects Methylene Blue / chemistry Rheology Temperature Viscosity
Antibacterial activity Methicillin resistant Staphylococcus aureus (MRSA) Methylene blue Multidrug resistance Skin wound infections Thermosensitive hydrogel

Journal

Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Titre abrégé: J Photochem Photobiol B
Pays: Switzerland
ID NLM: 8804966

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 05 06 2019
revised: 28 10 2019
accepted: 03 01 2020
pubmed: 14 1 2020
medline: 14 2 2020
entrez: 14 1 2020
Statut: ppublish

Résumé

Due to the emergence of antibiotic resistance, antimicrobial photodynamic therapy (aPDT) has recently been demonstrated as a promising alternative to antibiotics to treat wound infections caused by multidrug-resistant (MDR) pathogens. This study aimed to evaluate the bacterial killing efficiency of aPDT mediated by methylene blue (MB) loaded thermosensitive hydrogels against methicillin-resistant Staphylococcus aureus (MRSA). Box-Behnken Design method was employed to investigate the impacts of the polymer compositions, Poloxamer 407, Poloxamer 188 and Carbopol 934P, on the gelation temperature (T

Identifiants

DOI: 10.1016/j.jphotobiol.2020.111776 PMID: 31931388
pubmed: 31931388
pii: S1011-1344(19)30710-9
doi: 10.1016/j.jphotobiol.2020.111776
pii:
doi:

Substances chimiques

Anti-Infective Agents 0
Drug Carriers 0
Hydrogels 0
Methylene Blue T42P99266K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111776

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Brian Leung (B)

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Department of Life Sciences, Imperial College London, London, UK.

Priyanga Dharmaratne (P)

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Wei Yan (W)

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Ben C L Chan (BCL)

Institute of Chinese Medicine, State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong.

Clara B S Lau (CBS)

Institute of Chinese Medicine, State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong.

Kwok-Pui Fung (KP)

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Margaret Ip (M)

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Sharon S Y Leung (SSY)

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: sharon.leung@cuhk.edu.hk.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Development of thermosensitive hydrogel...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Development of thermosensitive hydrogel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Development of thermosensitive hydrogel...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Development of thermosensitive hydrogel...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Development of thermosensitive hydrogel...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Development of thermosensitive hydrogel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénothiazines › Bleu de méthylène › Development of thermosensitive hydrogel...
questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Rhéologie › Development of thermosensitive hydrogel...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Development of thermosensitive hydrogel...
questionsmedicales.fr › Phénomènes chimiques › Viscosité › Development of thermosensitive hydrogel...