Prevalence and antifungal susceptibility of Candida albicans causing vaginal discharge among pregnant women in Lebanon.
Adult
Amphotericin B
/ therapeutic use
Antifungal Agents
/ therapeutic use
Candida albicans
/ drug effects
Candida glabrata
/ drug effects
Candidiasis, Vulvovaginal
/ drug therapy
Cross-Sectional Studies
Drug Resistance, Fungal
/ drug effects
Female
Fluconazole
/ therapeutic use
Follow-Up Studies
Humans
Incidence
Infant, Newborn
Itraconazole
/ therapeutic use
Lebanon
/ epidemiology
Microbial Sensitivity Tests
Pregnancy
Prevalence
Vaginal Discharge
/ microbiology
Voriconazole
/ therapeutic use
Antifungal susceptibility
Candida albicans
Pregnant women
Prevalence
Vulvovaginitis
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
13 Jan 2020
13 Jan 2020
Historique:
received:
18
07
2019
accepted:
24
12
2019
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Vaginal candidiasis is frequent in pregnant women and is associated with sepsis and adverse neonatal outcomes. This study determined the prevalence of candida species in symptomatic pregnant women and evaluated the antifungal susceptibility profile of the isolated Candida strains. It also aimed to explore whether Candida species predicts gestational complications and adverse neonatal outcomes. A total of 258 pregnant women with vaginal discharge at 35 to 37 week of gestation participated in this study. Vaginal swabs from these patients were collected at various obstetrics and gynecology clinics in Lebanon for a period of 14 months. Candida isolates were identified at species level and antifungal susceptibility of Candida albicans to fluconazole (FCZ), amphotericin B (AMB), itraconazole (ICZ) and voriconazole (VCZ) was determined by the agar-based E-test method. Among 258 women tested, 100 (39%) were positive for Candida species. C. albicans, C. glabrata and C. krusei were isolated from 42, 41 and 17% of the women, respectively. C. albicans was significantly associated only with gestational diabetes while C. krusei or C. glabrata had significant positive associations with other gestational complications. The antifungal susceptibility tests of C. albicans isolates revealed 97.5, 90, 87.5 and 97.5% susceptibility to AMB, FCZ, ICZ and VCZ, respectively. The current study revealed high incidence of both C. albicans and non-C. albicans Candida strains causing vulvovaginitis among pregnant women in Beirut, Lebanon. Candida screening as antenatal follow up is advised to minimize the risk of adverse neonatal outcome or gestational complications.
Sections du résumé
BACKGROUND
BACKGROUND
Vaginal candidiasis is frequent in pregnant women and is associated with sepsis and adverse neonatal outcomes. This study determined the prevalence of candida species in symptomatic pregnant women and evaluated the antifungal susceptibility profile of the isolated Candida strains. It also aimed to explore whether Candida species predicts gestational complications and adverse neonatal outcomes.
METHODS
METHODS
A total of 258 pregnant women with vaginal discharge at 35 to 37 week of gestation participated in this study. Vaginal swabs from these patients were collected at various obstetrics and gynecology clinics in Lebanon for a period of 14 months. Candida isolates were identified at species level and antifungal susceptibility of Candida albicans to fluconazole (FCZ), amphotericin B (AMB), itraconazole (ICZ) and voriconazole (VCZ) was determined by the agar-based E-test method.
RESULTS
RESULTS
Among 258 women tested, 100 (39%) were positive for Candida species. C. albicans, C. glabrata and C. krusei were isolated from 42, 41 and 17% of the women, respectively. C. albicans was significantly associated only with gestational diabetes while C. krusei or C. glabrata had significant positive associations with other gestational complications. The antifungal susceptibility tests of C. albicans isolates revealed 97.5, 90, 87.5 and 97.5% susceptibility to AMB, FCZ, ICZ and VCZ, respectively.
CONCLUSION
CONCLUSIONS
The current study revealed high incidence of both C. albicans and non-C. albicans Candida strains causing vulvovaginitis among pregnant women in Beirut, Lebanon. Candida screening as antenatal follow up is advised to minimize the risk of adverse neonatal outcome or gestational complications.
Identifiants
pubmed: 31931738
doi: 10.1186/s12879-019-4736-2
pii: 10.1186/s12879-019-4736-2
pmc: PMC6958632
doi:
Substances chimiques
Antifungal Agents
0
Itraconazole
304NUG5GF4
Amphotericin B
7XU7A7DROE
Fluconazole
8VZV102JFY
Voriconazole
JFU09I87TR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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