Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure.
Adolescent
Adult
Aged
Animals
Anopheles
/ parasitology
Antibodies, Protozoan
/ blood
Child
Child, Preschool
Female
Humans
Immunoglobulin G
/ blood
Incidence
Infant
Malaria, Falciparum
/ diagnosis
Male
Microspheres
Middle Aged
Mosquito Vectors
/ parasitology
Plasmodium falciparum
/ immunology
Rain
Seasons
Senegal
/ epidemiology
Seroepidemiologic Studies
Transients and Migrants
Young Adult
Antibodies
CSP
Fulani
LSA-1
MSP-119
Malaria
Plasmodium
Senegal
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
13 Jan 2020
13 Jan 2020
Historique:
received:
31
10
2019
accepted:
09
01
2020
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150-450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys. A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-1 In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-1 Prevalence of P. falciparum MSP-1
Sections du résumé
BACKGROUND
BACKGROUND
Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150-450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys.
METHODS
METHODS
A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-1
RESULTS
RESULTS
In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-1
CONCLUSION
CONCLUSIONS
Prevalence of P. falciparum MSP-1
Identifiants
pubmed: 31931834
doi: 10.1186/s12936-020-3114-2
pii: 10.1186/s12936-020-3114-2
pmc: PMC6958760
doi:
Substances chimiques
Antibodies, Protozoan
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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