Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals.
Aged
Alzheimer Disease
/ diagnosis
Amyloidogenic Proteins
/ cerebrospinal fluid
Biomarkers
/ cerebrospinal fluid
Cerebrovascular Disorders
/ diagnosis
Cognitive Reserve
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging
Neuropsychological Tests
White Matter
/ diagnostic imaging
tau Proteins
/ cerebrospinal fluid
Alzheimer's disease
Amyloid
Biomarkers
Cerebrovascular disease
Cognitive reserve
Tau
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
14
06
2019
revised:
27
09
2019
accepted:
06
12
2019
pubmed:
15
1
2020
medline:
24
9
2020
entrez:
15
1
2020
Statut:
ppublish
Résumé
We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studies of AD were measured longitudinally: cerebrospinal fluid measures of amyloid (A) and tau (T); cerebrospinal fluid and neuroimaging measures of neuronal injury (N); and neuroimaging measures of white matter hyperintensities (WMHs) to assess cerebrovascular pathology (V). CR was indexed by a composite score including years of education, reading, and vocabulary test performance. Higher CR was associated with lower levels of WMHs, particularly among those who subsequently progressed from normal cognition to MCI. CR was not associated with WMH trajectories. In addition, CR was not associated with either levels of, or rate of change in, A/T/N biomarkers. This may suggest that higher CR is associated with lifestyle factors that reduce levels of cerebrovascular disease, allowing individuals with higher CR to better tolerate other types of pathology.
Identifiants
pubmed: 31932050
pii: S0197-4580(19)30431-2
doi: 10.1016/j.neurobiolaging.2019.12.003
pmc: PMC7160864
mid: NIHMS1569536
pii:
doi:
Substances chimiques
Amyloidogenic Proteins
0
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-41Subventions
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015909
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005146
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG033655
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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