Primary angiosarcoma of the breast: a case report.
Breast neoplasms
angiosarcoma
malignant
sarcoma
Journal
International journal of clinical and experimental pathology
ISSN: 1936-2625
Titre abrégé: Int J Clin Exp Pathol
Pays: United States
ID NLM: 101480565
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
09
2018
accepted:
27
09
2018
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
15
1
2020
Statut:
epublish
Résumé
Primary angiosarcoma of the breast is extremely rare, accounting for less than 0.05% of all primary malignancies of the breast. Here, we report here a case of primary angiosarcoma with full description of radiology and histology, including electron microscopic findings. A 39-year-old woman complained of a diffuse hard mass in her right breast. She did not have any history of radiation exposure. Ultrasonography revealed a 7 cm sized mass with an irregular anechoic cystic portion replacing the entire right breast. Modified radical mastectomy was performed. The diagnosis of intermediate grade angiosarcoma was made by microscopic examination, immunohistochemical staining, and electron microscopic examination. The patient underwent four cycles of adriamycin-ifosfamide chemotherapy and received radiation therapy. Multiple bone metastases occurred 9 months after surgery and palliative treatment was given. Follow up was lost at post-operative 22 months. We report a rare case of intermediate grade primary angiosarcoma with detailed radiological and histological findings. Despite postoperative chemoradiation therapy, multiple metastases suggest that intermediate grade may have a more aggressive behavior.
Sections du résumé
BACKGROUND
BACKGROUND
Primary angiosarcoma of the breast is extremely rare, accounting for less than 0.05% of all primary malignancies of the breast. Here, we report here a case of primary angiosarcoma with full description of radiology and histology, including electron microscopic findings.
CASE PRESENTATION
METHODS
A 39-year-old woman complained of a diffuse hard mass in her right breast. She did not have any history of radiation exposure. Ultrasonography revealed a 7 cm sized mass with an irregular anechoic cystic portion replacing the entire right breast. Modified radical mastectomy was performed. The diagnosis of intermediate grade angiosarcoma was made by microscopic examination, immunohistochemical staining, and electron microscopic examination. The patient underwent four cycles of adriamycin-ifosfamide chemotherapy and received radiation therapy. Multiple bone metastases occurred 9 months after surgery and palliative treatment was given. Follow up was lost at post-operative 22 months.
CONCLUSIONS
CONCLUSIONS
We report a rare case of intermediate grade primary angiosarcoma with detailed radiological and histological findings. Despite postoperative chemoradiation therapy, multiple metastases suggest that intermediate grade may have a more aggressive behavior.
Types de publication
Case Reports
Langues
eng
Pagination
664-668Informations de copyright
IJCEP Copyright © 2019.
Déclaration de conflit d'intérêts
None.
Références
J Clin Pathol. 2016 May;69(5):373-81
pubmed: 26729013
J Surg Oncol. 2004 Sep 1;87(3):121-5
pubmed: 15334638
Radiology. 2007 Mar;242(3):725-34
pubmed: 17325063
Cancer. 2007 Jul 1;110(1):173-8
pubmed: 17541936
BMC Cancer. 2017 Apr 27;17(1):295
pubmed: 28449661
Am J Clin Oncol. 2007 Oct;30(5):461-5
pubmed: 17921704
Breast Cancer. 2016 Sep;23(5):718-23
pubmed: 26243043
Am J Surg Pathol. 1981 Oct;5(7):629-42
pubmed: 7199829
Cancer. 2005 Dec 15;104(12):2682-8
pubmed: 16288486
Am J Surg Pathol. 2008 Dec;32(12):1896-904
pubmed: 18813119
Cancer. 1988 Nov 15;62(10):2145-51
pubmed: 3179927
Br J Cancer. 2004 Jul 19;91(2):237-41
pubmed: 15187996
AJR Am J Roentgenol. 2008 Feb;190(2):533-8
pubmed: 18212243
J Surg Oncol. 2010 Apr 1;101(5):401-7
pubmed: 20119983
Am J Clin Oncol. 2007 Dec;30(6):570-3
pubmed: 18091049