Sarcomatoid change associated with epithelial-mesenchymal transition in mucinous tubular and spindle cell carcinoma of the kidney: a case report.
Epithelial mesenchymal transition
ZEB1
mucinous tubular and spindle cell carcinoma
renal cell cancer
sarcomatoid change
Journal
International journal of clinical and experimental pathology
ISSN: 1936-2625
Titre abrégé: Int J Clin Exp Pathol
Pays: United States
ID NLM: 101480565
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
02
2019
accepted:
22
05
2019
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
15
1
2020
Statut:
epublish
Résumé
We report an unusual case of mucinous tubular and spindle cell carcinoma (MTSCC) with sarcomatoid change in an 80-year-old Japanese male. In a resected specimen, a grayish-white tumor was found in the left kidney, and several metastases were observed in the right cervical bone and liver. Histologically, most of the main tumor examined showed MTSCC with sarcomatoid change. The transitions between the MTSCC and sarcomatoid components suggested that sarcomatoid transformation had occurred in the MTSCC. Immunohistochemically, the epithelial-mesenchymal transition (EMT)-associated marker ZEB1 was expressed in the sarcomatoid and transitional components. In contrast, ZEB1 expression was negative in the MTSCC component. The present findings support the view that MTSCC with sarcomatoid change represents MTSCC that develops a sarcomatoid component via EMT of the MTSCC component. EMT plays an important role in sarcomatoid change; thus, we conclude that MTSCC with sarcomatoid change is an 'EMT associated tumor'.
Types de publication
Case Reports
Langues
eng
Pagination
2767-2771Informations de copyright
IJCEP Copyright © 2019.
Déclaration de conflit d'intérêts
None.
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