Effects of centrifugation and whole-body vibrations on blood-brain barrier permeability in mice.
Neuroscience
Physiology
Journal
NPJ microgravity
ISSN: 2373-8065
Titre abrégé: NPJ Microgravity
Pays: United States
ID NLM: 101703605
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
09
2019
accepted:
06
12
2019
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
15
1
2020
Statut:
epublish
Résumé
Modifications of gravity levels induce generalized adaptation of mammalian physiology, including vascular, brain, muscle, bone and immunity functions. As a crucial interface between the vascular system and the brain, the blood-brain barrier (BBB) acts as a filter to protect neurons from pathogens and inflammation. Here we compare the effects of several protocols of hypergravity induced by centrifugation and whole-body vibrations (WBV) on BBB integrity. The immunohistochemistry revealed immunoglobulin G (IgG) extravasation from blood to hippocampal parenchyma of mice centrifuged at 2 ×
Identifiants
pubmed: 31934612
doi: 10.1038/s41526-019-0094-z
pii: 94
pmc: PMC6946672
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsAll authors declare that they have no conflict of interest and no competing interest. The work was done in the laboratories of the authors. Protocols applied to mice were performed in SINBIO U1059, samples were treated in UMR8002 and analysed in UMR5293.
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