CGF Treatment of Leg Ulcers: a Randomized Controlled Trial.
CGF
Concentrated Growth Factors
Leg ulcers
Mixed ulcers
PRP
Platlet Rich Plasma
Vascular ulcers
Journal
Open medicine (Warsaw, Poland)
ISSN: 2391-5463
Titre abrégé: Open Med (Wars)
Pays: Poland
ID NLM: 101672167
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
04
2019
accepted:
04
10
2019
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
15
1
2020
Statut:
epublish
Résumé
Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers. The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process. Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study. The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities. These results support the CGF's clinical use for improving clinical outcomes in mixed ulcers of the legs.
Sections du résumé
BACKGROUND
BACKGROUND
Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.
AIM
OBJECTIVE
The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.
METHODS
METHODS
Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.
RESULTS
RESULTS
The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.
CONCLUSIONS
CONCLUSIONS
These results support the CGF's clinical use for improving clinical outcomes in mixed ulcers of the legs.
Identifiants
pubmed: 31934641
doi: 10.1515/med-2019-0113
pii: med-2019-0113
pmc: PMC6947757
doi:
Types de publication
Journal Article
Langues
eng
Pagination
959-967Informations de copyright
© 2019 Bruno Amato et al., published by De Gruyter.
Déclaration de conflit d'intérêts
Conflict of interest Conflict of interest statement: Authors state no conflict of interest
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