Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance.
Anti-HIV Agents
/ chemistry
Cryoelectron Microscopy
Crystallography, X-Ray
Drug Resistance, Viral
HIV Reverse Transcriptase
/ antagonists & inhibitors
HIV-1
/ enzymology
Humans
Macromolecular Substances
/ chemistry
Models, Molecular
Molecular Structure
Mutation
Protein Binding
Protein Conformation
Reverse Transcriptase Inhibitors
/ chemistry
Structure-Activity Relationship
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
28
10
2019
accepted:
28
11
2019
pubmed:
15
1
2020
medline:
8
6
2021
entrez:
15
1
2020
Statut:
ppublish
Résumé
The essential role of reverse transcription in the HIV life cycle is illustrated by the fact that half of the ∼30 FDA-approved drugs for HIV treatment target HIV-1 reverse transcriptase (RT). Even though more than 160 structures of RT deposited in the Protein Data Bank (PDB) have revealed the molecular architecture of RT in great detail, some key states of RT function and inhibition remain still unknown. Recent structures of RT initiation complexes, RT poised for RNA hydrolysis, and RT with approved drugs and investigational compounds have provided a deeper understanding of RT function and inhibition, suggesting novel avenues for targeting this central enzyme of HIV.
Identifiants
pubmed: 31935541
pii: S0959-440X(19)30137-X
doi: 10.1016/j.sbi.2019.11.011
pmc: PMC7596924
mid: NIHMS1569517
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Macromolecular Substances
0
Reverse Transcriptase Inhibitors
0
reverse transcriptase, Human immunodeficiency virus 1
EC 2.7.7.-
HIV Reverse Transcriptase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-123Subventions
Organisme : NIAID NIH HHS
ID : R01 AI027690
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI027690
Pays : United States
Organisme : NIAID NIH HHS
ID : U54 AI150472
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM103368
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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