Recent human genetic errors of innate immunity leading to increased susceptibility to infection.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
13
08
2019
revised:
05
12
2019
accepted:
09
12
2019
pubmed:
15
1
2020
medline:
30
6
2021
entrez:
15
1
2020
Statut:
ppublish
Résumé
The germline encoded innate immunity governs eukaryotic host defense through both hematopoietic and non-hematopoietic cells, whereas adaptive immunity actions mainly via T cells and B cells characterized by their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity typically underlie infectious diseases. Disturbed innate immunity can additionally result in auto-inflammation. Here, we review inborn errors of innate immunity that have been recently discovered as well as new insights into previously described inborn errors of innate immunity.
Identifiants
pubmed: 31935567
pii: S0952-7915(19)30099-8
doi: 10.1016/j.coi.2019.12.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-90Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.