Poly(Ethylene Glycol) Crosslinked Multi-Armed Poly(l-Lysine) with Encapsulating Capacity and Antimicrobial Activity for the Potential Treatment of Infection-Involved Multifactorial Diseases.
antimicrobial polymer
drug delivery systems
multifactorial diseases
polyion complex micelles
shell crosslinked micelles
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
06 Jan 2020
06 Jan 2020
Historique:
received:
17
11
2019
revised:
23
12
2019
accepted:
03
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
epublish
Résumé
With the development of modern medical technology, common diseases usually can be treated by traditional medicines and their formulation, while diseases with multiple etiologies still remain a great challenge in clinic. Nanoformulation was widely explored to address this problem. However, due to limited drug loading space of nanocarriers, co-delivery strategy usually fails to achieve sufficient loading of multiple drugs simultaneously. In this research, we explored the potential of poly(ethylene glycol) (PEG) crosslinked alternating copolymers MPLL-
Identifiants
pubmed: 31935837
pii: pharmaceutics12010047
doi: 10.3390/pharmaceutics12010047
pmc: PMC7022689
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : China Postdoctoral Science Foundation
ID : No. 2018M633259
Organisme : National Natural Science Foundation of China
ID : No. 81803467
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