Biosynthesis of Galactan in
GlfT1
GlfT2
UDP-galactose mutase
cell wall
drug design
galactofuranosyl transferase
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
06 Jan 2020
06 Jan 2020
Historique:
received:
17
12
2019
revised:
27
12
2019
accepted:
02
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
epublish
Résumé
While target-based drug design has proved successful in several therapeutic areas, this approach has not yet provided compelling outcomes in the field of antibacterial agents. This statement remains especially true for the development of novel therapeutic interventions against tuberculosis, an infectious disease that is among the top ten leading causes of death globally. Mycobacterial galactan is an important component of the protective cell wall core of the tuberculosis pathogen and it could provide a promising target for the design of new drugs. In this review, we summarize the current knowledge on galactan biosynthesis in
Identifiants
pubmed: 31935842
pii: antibiotics9010020
doi: 10.3390/antibiotics9010020
pmc: PMC7168186
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agentúra na Podporu Výskumu a Vývoja
ID : APVV-15-0515
Organisme : Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
ID : VEGA 2/0137/20
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