ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (geno)Toxicity Screening of Nanoparticles-Metals, Oxides and Quantum Dots.
DNA damage
genotoxicity
high throughput screening
metal oxides
nanotoxicology
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
06 Jan 2020
06 Jan 2020
Historique:
received:
28
11
2019
revised:
20
12
2019
accepted:
25
12
2019
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
epublish
Résumé
The increased use of nanoparticles (NPs) requires efficient testing of their potential toxic effects. A promising approach is to use reporter cell lines to quickly assess the activation of cellular stress response pathways. This study aimed to use the ToxTracker reporter cell lines to investigate (geno)toxicity of various metal- or metal oxide NPs and draw general conclusions on NP-induced effects, in combination with our previous findings. The NPs tested in this study (
Identifiants
pubmed: 31935871
pii: nano10010110
doi: 10.3390/nano10010110
pmc: PMC7023144
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The Swedish Research Council (VR)
ID : 2014-4598
Organisme : The Swedish Research Council (VR)
ID : 2017-03931
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