Increased Cardiovascular Risk Associated with Chemical Sensitivity to Perfluoro-Octanoic Acid: Role of Impaired Platelet Aggregation.
cardiovascular diseases
liquid chromatography-mass spectrometry, membrane fluidity, platelets’ aggregation
perfluoro–alkyl substances
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
received:
27
11
2019
revised:
20
12
2019
accepted:
03
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Perfluoro-alkyl substances (PFAS), particularly perfluoro-octanoic acid (PFOA), are persisting environmental chemicals showing bioaccumulation in human tissues. Recently, exposure to PFAS has been associated with increased prevalence of cardiovascular diseases (CVDs). However, a causal role of PFAS in atherosclerosis pathogenesis is under-investigated. Here, we investigated the effect of PFOA exposure on platelets' function, a key player in atherosclerosis process. PFOA accumulation in platelets was evaluated by liquid chromatography-mass spectrometry. Changes in platelets' membrane fluidity and activation after dose-dependent exposure to PFOA were evaluated by merocyanine 540 (MC540) and anti P-Selectin immune staining at flow cytometry, respectively. Intracellular calcium trafficking was analyzed with Fluo4M probe, time-lapse live imaging. Platelets' aggregation state was also evaluated with Multiplate
Identifiants
pubmed: 31936344
pii: ijms21020399
doi: 10.3390/ijms21020399
pmc: PMC7014465
pii:
doi:
Substances chimiques
Caprylates
0
Fluorocarbons
0
Water Pollutants, Chemical
0
perfluorooctane
6P60ZBK0QL
octanoic acid
OBL58JN025
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
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