Flow Cytometry-Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation-A Proof-of-Concept Study.
cardiopulmonary bypass
coagulopathy
inflammation
major abdominal surgery
sepsis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
08 Jan 2020
08 Jan 2020
Historique:
received:
12
12
2019
revised:
27
12
2019
accepted:
04
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
epublish
Résumé
This proof-of-concept study aimed to evaluate a novel method of flow cytometry-based quantification of neutrophil extracellular traps (NETs) in septic shock patients and to identify possible interactions between the number of free-circulating NETs and alterations of the coagulatory system. Patients suffering from septic shock, a matched control group (CTRL), and patients suffering from systemic inflammation after cardiac (CABG) or major abdominal surgery (MAS) were enrolled in this prospective proof-of-concept study. Compared to the matched controls, free-circulating NETs were significantly elevated in septic shock and postsurgical patients (data are presented in median (IQR)); septic shock: (2.7 (1.9-3.9); CABG: 2.7 (2.1-3.7); MAS: 2.7 (2.1-3.9); CTRL: 1.6 (1-2); CTRL vs. septic shock:
Identifiants
pubmed: 31936385
pii: jcm9010174
doi: 10.3390/jcm9010174
pmc: PMC7019434
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsches Zentrum für Infektionsforschung
ID : TI 07.001_Schneck_00
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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