Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models.
Hirudo medicinalis
microgravity
platelet rich plasma
wound healing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jan 2020
09 Jan 2020
Historique:
received:
30
10
2019
revised:
22
12
2019
accepted:
23
12
2019
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reasons: (i) defining tools, procedures, and protocols to manage serious wounds and burns eventually occurring in future long-lasting space exploration missions, without the possibility of timely medical evacuation to Earth; (ii) understanding the role of gravity and mechanical factors in the healing process and scarring, thus contributing to unravelling the mechanisms underlying the switching between perfect regeneration and imperfect repair with scarring. In the study presented here, a new in vivo sutured wound healing model in the leech (
Identifiants
pubmed: 31936443
pii: ijms21020407
doi: 10.3390/ijms21020407
pmc: PMC7013931
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agenzia Spaziale Italiana
ID : 2013-090-R.O
Organisme : Agenzia Spaziale Italiana
ID : 2018-14-U.0
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