Significance of 5-
5-S-cysteinyldopa (5SCD)
Melanoma inhibitory activity (MIA)
S100 calcium-binding protein B (S100B)
anti-programmed cell death protein (PD)-1 antibody
biomarker
early detection
hepatocyte growth factor (HGF)
lactate dehydrogenase (LDH)
melanoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jan 2020
09 Jan 2020
Historique:
received:
25
11
2019
revised:
07
01
2020
accepted:
07
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Melanoma is one of the most lethal and malignant cancers and its incidence is increasing worldwide, and Japan is not an exception. Although there are numerous therapeutic options for melanoma, the prognosis is still poor once it has metastasized. The main concern after removal of a primary melanoma is whether it has metastasized, and early detection of metastatic melanoma would be effective in improving the prognosis of patients. Thus, it is very important to identify reliable methods to detect metastases as early as possible. Although many prognostic biomarkers (mainly for metastases) of melanoma have been reported, there are very few effective for an early diagnosis. Serum and urinary biomarkers for melanoma diagnosis have especially received great interest because of the relative ease of sample collection and handling. Several serum and urinary biomarkers appear to have significant potential both as prognostic indicators and as targets for future therapeutic methods, but still there are no efficient serum and urinary biomarkers for early detection, accurate diagnosis and prognosis, efficient monitoring of the disease and reliable prediction of survival and recurrence. Levels of 5-
Identifiants
pubmed: 31936623
pii: ijms21020432
doi: 10.3390/ijms21020432
pmc: PMC7013534
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Cysteinyldopa
19641-92-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Scholarship donation
ID : Fujita Health University
Organisme : Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture
ID : 02670487
Organisme : the Ministry of Health and Welfare, no. 3-20, Japan, and for Cancer Research from the Ministry of Health, Labour and Welfare of Japan
ID : 11-7
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : 18K08301
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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