Apoptosis
/ drug effects
Astrocytes
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Cisplatin
/ pharmacology
Gardenia
/ chemistry
Gene Expression Regulation, Neoplastic
/ drug effects
Glioblastoma
/ drug therapy
Humans
Proto-Oncogene Proteins c-akt
/ genetics
TOR Serine-Threonine Kinases
/ genetics
AKT/mTOR pathway
Gardenia jasminoides
apoptosis
autophagy
cisplatin (CDDP)
glioblastoma
synergy
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Jan 2020
10 Jan 2020
Historique:
received:
24
12
2019
revised:
05
01
2020
accepted:
07
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
24
10
2020
Statut:
epublish
Résumé
Gliomas are the most observed primary brain tumor, of which glioblastoma multiform (GBM) shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic method, but because of side effects, search for alternative therapies is required.
Identifiants
pubmed: 31936835
pii: nu12010196
doi: 10.3390/nu12010196
pmc: PMC7019269
pii:
doi:
Substances chimiques
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Korean Medicine R&D Project of the Ministry of Health and Welfare
ID : HI11C2110
Organisme : Korean Medicine R&D Project of the Ministry of Health and Welfare
ID : HI18C2382
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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