The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease: Conventionally Pathogenetic or Unconventionally Protective?
Alzheimer′s disease
macrophage migration inhibitory factor
neuroinflammation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Jan 2020
10 Jan 2020
Historique:
received:
18
12
2019
revised:
03
01
2020
accepted:
09
01
2020
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
5
6
2020
Statut:
epublish
Résumé
Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer's disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.
Identifiants
pubmed: 31936865
pii: molecules25020291
doi: 10.3390/molecules25020291
pmc: PMC7024279
pii:
doi:
Substances chimiques
Macrophage Migration-Inhibitory Factors
0
Receptors, Immunologic
0
macrophage migration inhibitory factor receptor
0
Intramolecular Oxidoreductases
EC 5.3.-
MIF protein, human
EC 5.3.2.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Prog Mol Biol Transl Sci. 2019;168:205-217
pubmed: 31699315
Acta Pharmacol Sin. 2018 Sep;39(9):1421-1438
pubmed: 29770796
J Affect Disord. 2020 Feb 15;263:15-24
pubmed: 31818772
Alzheimers Res Ther. 2017 Mar 4;9(1):14
pubmed: 28259169
Neuron. 2015 Apr 8;86(1):218-32
pubmed: 25801706
Biochim Biophys Acta. 2000 Jun 15;1479(1-2):91-102
pubmed: 11004532
Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):423-31
pubmed: 10817926
Crit Rev Immunol. 1997;17(1):77-88
pubmed: 9034724
Med Res Rev. 2016 May;36(3):440-60
pubmed: 26777977
J Psychiatr Res. 2009 May;43(8):749-53
pubmed: 19038405
Molecules. 2018 Sep 26;23(10):
pubmed: 30261624
Neural Regen Res. 2019 Jul;14(7):1158-1176
pubmed: 30804241
Arthritis Rheumatol. 2019 Jan;71(1):109-120
pubmed: 30009530
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10198-203
pubmed: 27551074
Expert Opin Ther Targets. 2019 Sep;23(9):733-744
pubmed: 31414920
Immunol Cell Biol. 2020 Jan;98(1):28-41
pubmed: 31654430
Head Neck. 2017 Dec;39(12):2573-2584
pubmed: 28963807
Dement Geriatr Cogn Disord. 2004;18(3-4):261-4
pubmed: 15286457
J Neurochem. 2016 Feb;136(3):457-74
pubmed: 26509334
Eur J Neurol. 2018 Jan;25(1):59-70
pubmed: 28872215
Oncol Lett. 2018 Sep;16(3):2881-2886
pubmed: 30127875
Cytokine. 2011 Aug;55(2):165-7
pubmed: 21550814
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8421-E8429
pubmed: 28923927
Oncotarget. 2016 Nov 8;7(45):73486-73496
pubmed: 27636991
Oncotarget. 2018 Apr 3;9(25):17951-17970
pubmed: 29707160
Curr Alzheimer Res. 2011 Mar;8(2):156-63
pubmed: 21345166
Cytokine. 2012 Jul;59(1):10-7
pubmed: 22507380
Orphanet J Rare Dis. 2017 May 25;12(1):100
pubmed: 28545481
Curr Alzheimer Res. 2016;13(4):403-12
pubmed: 26567742
J Immunol. 2015 Sep 1;195(5):2343-52
pubmed: 26209628
Ann Transl Med. 2018 May;6(10):177
pubmed: 29951499
Cancers (Basel). 2019 Apr 12;11(4):
pubmed: 31013837
Liver Int. 2006 Apr;26(3):346-51
pubmed: 16584398
Cell Signal. 2019 May;57:76-88
pubmed: 30682543
Alzheimers Dement. 2020 Feb;16(2):292-304
pubmed: 31630996
Brain Sci. 2019 Oct 19;9(10):
pubmed: 31635049
J Clin Invest. 2009 Dec;119(12):3807-16
pubmed: 19920350
Am J Pathol. 2003 Jan;162(1):47-56
pubmed: 12507889
Neurosci Bull. 2016 Oct;32(5):469-80
pubmed: 27568024
Expert Opin Ther Targets. 2017 Jul;21(7):671-683
pubmed: 28562118
Alzheimers Dement. 2016 Mar;12(3):292-323
pubmed: 27012484
Leuk Res. 2015 Oct;39(10):1088-95
pubmed: 26220866
Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14755-14760
pubmed: 31262807
Drug Discov Today. 2019 Feb;24(2):428-439
pubmed: 30439447
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
J Biol Chem. 2012 Mar 2;287(10):7446-55
pubmed: 22238348
Immunotherapy. 2018 Feb 1;10(4):265-282
pubmed: 29421983
Mol Med Rep. 2019 Sep;20(3):2135-2142
pubmed: 31322215
Antioxid Redox Signal. 2011 May 15;14(10):1829-39
pubmed: 21194385
Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):306-15
pubmed: 25903922
Clin Med (Lond). 2016 Jun;16(3):247-53
pubmed: 27251914
Nat Rev Neurol. 2018 Jul;14(7):399-415
pubmed: 29895964
Sci Rep. 2017 Feb 23;7:42874
pubmed: 28230058
FASEB J. 2014 Oct;28(10):4394-407
pubmed: 24970391
Neurodegener Dis. 2014;13(4):230-6
pubmed: 24022074
Neuroscience. 2019 Sep 15;416:50-62
pubmed: 31170483
Front Pharmacol. 2019 Apr 12;10:377
pubmed: 31031625
N Engl J Med. 2018 Aug 30;379(9):846-855
pubmed: 30157388
Mol Med. 2010 Mar;16(3-4):116-21
pubmed: 20200619
Immunol Lett. 2008 Dec 22;121(2):105-9
pubmed: 18930766
Cytokine. 2020 Jan;125:154792
pubmed: 31400637
Genes (Basel). 2019 Nov 18;10(11):
pubmed: 31752120
PLoS One. 2012;7(11):e49350
pubmed: 23139842
CNS Neurosci Ther. 2018 Oct;24(10):876-888
pubmed: 30058285
Cell Death Dis. 2018 Jan 25;9(2):107
pubmed: 29371591
Curr Opin Psychiatry. 2019 Mar;32(2):123-129
pubmed: 30557268
Biol Pharm Bull. 2019;42(6):1044-1047
pubmed: 31155581
Alzheimers Res Ther. 2019 Jun 7;11(1):54
pubmed: 31174614
J Neuroinflammation. 2005 Mar 11;2(1):9
pubmed: 15762998
Medicina (Kaunas). 2019 Oct 01;55(10):
pubmed: 31581595
Invest New Drugs. 2019 Oct;37(5):1014-1028
pubmed: 30706336
J Neuroimmunol. 2018 Sep 15;322:46-56
pubmed: 29935880
Mol Carcinog. 2019 Aug;58(8):1362-1375
pubmed: 30997718
Nat Med. 2012 Dec;18(12):1812-9
pubmed: 23178247
Brain Behav Immun. 2017 May;62:203-211
pubmed: 28161476
J Neuroinflammation. 2015 Sep 17;12:177
pubmed: 26382037
Nat Commun. 2018 Jun 8;9(1):2223
pubmed: 29884801
Nat Rev Urol. 2019 May;16(5):318-328
pubmed: 30914802
J Intern Med. 2014 Mar;275(3):251-83
pubmed: 24605808