A Review of the Role of Carcinoembryonic Antigen in Clinical Practice.
Carcinoembryonic antigen
Colorectal cancer
Recurrence
Journal
Annals of coloproctology
ISSN: 2287-9714
Titre abrégé: Ann Coloproctol
Pays: Korea (South)
ID NLM: 101605121
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
29
07
2019
accepted:
13
11
2019
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
ppublish
Résumé
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.
Identifiants
pubmed: 31937069
pii: ac.2019.11.13
doi: 10.3393/ac.2019.11.13
pmc: PMC6968721
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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