Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
09 Jan 2020
09 Jan 2020
Historique:
received:
09
09
2019
accepted:
03
12
2019
entrez:
16
1
2020
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
epublish
Résumé
Thus far, no accurate measurement technology has been developed to detect lipid alkyl radicals (lipid radicals), which cause lipid peroxidation. Therefore, we aimed to develop a nuclear medical imaging probe that can be taken up in the lipophilic site in cells such as biological membranes, by reacting specifically with the lipid radicals generated there. We designed and synthesized 4-(4-[
Identifiants
pubmed: 31938462
doi: 10.1021/acsmedchemlett.9b00416
pmc: PMC6956360
doi:
Types de publication
Journal Article
Langues
eng
Pagination
45-48Informations de copyright
Copyright © 2019 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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