In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites.
Acanthamoeba castellanii
/ drug effects
Amebicides
/ chemistry
Animals
Brain
/ blood supply
Cells, Cultured
Endothelial Cells
Environment
Hemolysis
Humans
Imidazoles
/ chemistry
Inhibitory Concentration 50
Kinetics
Magnetic Resonance Imaging
Mice
Parasitic Sensitivity Tests
RAW 264.7 Cells
Trophozoites
/ drug effects
Acanthamoeba
Amoebic encephalitis
Clinical and environmental isolates
Imidazolium ionic liquids
In vitro cytotoxicity
Keratitis
Journal
Acta parasitologica
ISSN: 1896-1851
Titre abrégé: Acta Parasitol
Pays: Switzerland
ID NLM: 9301947
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
06
03
2019
accepted:
16
12
2019
pubmed:
16
1
2020
medline:
4
3
2021
entrez:
16
1
2020
Statut:
ppublish
Résumé
Several strains of the free-living genus Acanthamoeba can cause granulomatous amoebic encephalitis (GAE), a rare chronic and slowly progressive infection of the central nervous system (CNS), and Acanthamoeba keratitis (AK), a sight-threatening eye infectious disease. AK incidence has increased with the popularization of the contact lens wear and its treatment is currently limited and frequently unsuccessful. As imidazolium salts (IS), cationic imidazole derivatives, have promising antimicrobial potential. The present study evaluated the amoebicidal activity of four IS; 1-n-hexadecyl-3-methylimidazolium methanesulfonate (C Three IS showed being lethal to 100% of the Acanthamoeba trophozoites at the minimum inhibitory concentrations of 125 and 62.5 μg/mL (C Thus, C
Identifiants
pubmed: 31939031
doi: 10.2478/s11686-019-00161-6
pii: 10.2478/s11686-019-00161-6
doi:
Substances chimiques
Amebicides
0
Imidazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
317-326Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001