Exploring Dysregulated Signaling Pathways in Cancer.
Angiogenesis
apoptosis
cell invasion
cell proliferation
drug targets
metastasis
signaling pathways
tumor microenvironment.
Journal
Current pharmaceutical design
ISSN: 1873-4286
Titre abrégé: Curr Pharm Des
Pays: United Arab Emirates
ID NLM: 9602487
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
10
2019
accepted:
27
11
2019
pubmed:
16
1
2020
medline:
4
11
2020
entrez:
16
1
2020
Statut:
ppublish
Résumé
Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular mediators, as well as intracellular interactions that govern diverse cellular processes. Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to the improvement of targeted tumor therapy. In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed.
Identifiants
pubmed: 31939726
pii: CPD-EPUB-103653
doi: 10.2174/1381612826666200115095937
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
429-445Informations de copyright
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